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Acetylcholinesterase human

商品货号:C1682
商品品牌:Sigma
商品规格:0.1mg
上架时间:2012-04-22
本店售价:¥6675元
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品名:Acetylcholinesterase human

货号:C1682

品牌:Sigma

规格:0.1mg

 

Synonyms: Acetylcholine acetylhydrolase, AChE
CAS Number: 9000-81-1
Enzyme Commission (EC) Number: 3.1.1.7   ( BRENDA | IUBMB )
MDL number: MFCD00081268

Description

Analysis Note The activity obtained using acetylcholine as substrate is 30-100 times that obtained with butyrylcholine, using acetylcholinesterase from electric eel.
Biochem/physiol Actions Major degradative enzyme for acetylcholine in vivo. Converts acetylcholine + H2O to choline + acetic acid.
Packaging Package size based on protein content.
Unit Definition One unit will hydrolyze 1.0 μmole of acetylcholine to choline and acetate per min at pH 8.0 at 37 °C
Physical form Lyophilized powder containing phosphate buffer salt

Properties

recombinant expressed in HEK 293 cells
form lyophilized powder
Gene Information human ... ACHE(43)
storage temp. −20°C

Safety

Hazard Codes B
WGK Germany 3

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References

Reference Levinson, S., and Ellory, J., The molecular form of acetylcholinesterase as determined by irradiation inactivation. Biochem. J. 137, 123-125, (1974)
  Rosenberry, T.L., et al., Structure of the 11S acetylcholinesterase. Subunit composition. Biochemistry 13, 3068-3079, (1974)
  Anglister, I., and Silman, I., Molecular structure of elongated forms of electric eel acetylcholinesterase. J. Mol. Biol. 125, 293-311, (1978)
  Taylor, P., The cholinesterases. J. Biol. Chem. 266, 4025-4028, (1991)
  Soreq, H., et al. Proc. Natl. Acad. Sci. USA 87, 9688, (1990)
  Froede, H.C., and Wilson I.B., Direct determination of acetyl-enzyme intermediate in the acetylcholinesterase-catalyzed hydrolysis of acetylcholine and acetylthiocholine. J. Biol. Chem. 259, 11010-11013, (1984)
  Szegletes, T., et al., Substrate binding to the peripheral site of acetylcholinesterase initiates enzymatic catalysis. Substrate inhibition arises as a secondary effect. Biochemistry 38, 122-133, (1999)

 

Acetylcholinesterase human

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