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anti-p62 / SQSTM1, C terminus

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商品货号:GP62-C
商品品牌:Progen
商品规格:100ul
上架时间:2013-07-31
本店售价:¥5000元
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Cat. No. GP62-C
Synonyms sequestosome 1, ubiquitin-binding protein
Suitable for IHC, WB / paraffin (microwave), frozen sections
Presentation serum
Host guinea pig
Antibody Type polyclonal
Dilution for IHC 1:100
Species / Reactive with human, mouse, rat
Quantity 100 µL

 

Antigen
C-terminal domain (20 amino acids: C-NYD IGA ALD TIQ YSK HPP PL) of human p62 protein, coupled to KLH. This peptide sequence is identical in human, monkey, bovine, mouse, and rat.

Reactive Polypeptide (Specificity)
Human 62 kD (p62) protein, is present in intracytoplasmic inclusions (e.g. hyaline bodies) of hepatocellular carcinoma. p62 protein (also described as ubiqutin-binding protein; sequestosome 1; SQSTM1) has been found in many tissues and cells, including lymphoid cells, serving probably a common cellular signal transduction mechanism (e.g. ubiquitin-associated degradation and autophagy). The antiserum stains also neurofibrillary tangles in the brain of patients suffering from Alzheimer’s disease.

Suitable for

  • immunohistochemistry on frozen and paraffin* sections (*enhanced after microwave treatment)
  • cytological material - immunoblotting

Working Dilution
1: 100 – 1:200 for immunohistochemistry
1:1,000 – 1:2000 for Western blotting (ECL)

Incubation Time
1 h at RT; extended with paraffin sections

Volume
100 μl; contains 0.09% sodium azide

anti-p62 / SQSTM1, C terminus

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